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Phentermine is the most commonly prescribed prescription appetite suppressant, accounting for 50% of the prescriptions. Part of this reason is because it's significantly cheaper than the other major FDA-approved diet drugs, Meridia and Xenical.

Phentermine first received approval from the Food and Drug Administration (FDA) in 1959 as an appetite suppressant for the short-term treatment of obesity.

As Phentermine is an older drug, no new efficacy trials have been conducted. The one notable exception, are several trials on the combination of Phentermine and Fenfluramine in the early and mid 1990s.

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What side effects can this medication cause?

Although side effects from phentermine are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:

  • dry mouth
  • unpleasant taste
  • diarrhea
  • constipation
  • vomiting
If you experience any of the following symptoms, call your doctor immediately:
  • increased blood pressure
  • heart palpitations
  • restlessness
  • dizziness
  • tremor
  • insomnia
  • shortness of breath
  • chest pain
  • dizziness
  • swelling of the legs and ankles
  • difficulty doing exercise that you have been able to do

Side Effects

Along with its needed effects, Phentermine may cause unwanted side effects, some being symptoms of serious heart or lung problems.

Please consult your doctor immediately if you notice:

  • Chest pain
  • Decreased ability to exercise
  • Fainting
  • Swelling of feet or lower legs
  • Trouble in breathing
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.

Inform your doctor if any of the following side effects persist or are bothersome:

More Common Symptoms

  • Depression
  • Drowsiness
  • Increased blood pressure
  • Irritability
  • Nervousness
  • Sense of well-being
  • Tiredness
Less Common to Rare Symptoms

  • Blurred vision
  • Change in sexual desire
  • Clumsiness
  • Confusion
  • Diarrhea
  • Dizziness
  • Dry mouth
  • Headache
  • Irregular heartbeat
  • Nausea or vomiting
  • Psychosis
  • Skin rash or itching
  • Stomach pain
  • Tiredness
  • Unpleasant taste
Other side effects not listed above may occur in some patients. If you notice any other side effects, please inform your doctor.

Possible Overdose Symptoms:

Confusion Convulsions (seizures)
Dizziness Fast Breathing
Fever Hallucinations
Hostility with urge to attack Irregular blood pressure
Irregular heartbeat Lightheadedness or Fainting
Mental Depression, following a period of excitement Tremors, Trembling, or Shaking
Overactive Reflexes Panic
Restlessness Severe nausea, vomiting or diarrhea
Stomach cramps Tiredness or Weakness


Physical or Mental Dependence on Phentermine

If you have been taking Phentermine for a long time or in large doses and you think you may have become mentally or physically dependent on it, please speak to your doctor.

Some signs of dependence on Phentermine (or other appetite suppressants) are:

  • a strong desire or need to continue taking the medicine.
  • a need to increase the dose to receive the effects of the medicine.
Withdrawal side effects may include:

  • Changes in personality
  • Excessive, excited activity
  • Irritability (severe)
  • Extreme tiredness or weakness
  • Mental depression or illness (severe)
  • Nausea or vomiting
  • Skin disease
  • Stomach Cramps or Pain
  • Trembling
  • Trouble in Sleeping or Nightmares (severe)

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